Our analysis of cytokine responses to TB specific antigen stimulation revealed that individuals (HCWs and CCs) latently infected with M. tuberculosis had significantly increased M. tuberculosis IFN-γ and IL-2 responses compared to non-infected individuals, which is expected, as IFN-γ and IL-2 profiles have been associated with antigenic memory22–24. This evidence concerns the gene IL2 and tuberculosis.