CD4 and colitis: However, comparable proportions and absolute numbers of IL-17A-expressing CD4+ T cells (Th17) and Foxp3-expressing CD4+ T cells (Tregs) were found in the cLP of DSS-exposed mice regardless of GSK343 treatment (Supplementary Fig. 5a), indicating that both Th17 and Treg cells may not be critical for GSK343-mediated amelioration of DSS-induced colitis.