CCR2 and neoplasm: A similar effect of Ccr2 deletion was observed in spontaneous tumours in a NeuroD2:SmoA1;Ccr2RFP/RFP murine model, where the loss of CCR2 receptor resulted in a decrease of total Ly6Chi and Ly6ClowCD45hi cell number more than twofold, from 30% in NeuroD2:SmoA1 down to 13% in NeuroD2:SmoA1;Ccr2RFP/RFP (N = 7; Fig. 4g).