For the first time, we have characterised the immune TME cell composition of NeuroD2:SmoA1 murine SHH medulloblastoma and found that it predominantly consists of CD45hiCD11b+ BM-derived myeloid cells and CD45low microglial cells, with small fractions of CD45+Ly6G+ granulocytic cells and CD45+CD11b− lymphocytes. Here, PTPRC is linked to medulloblastoma.