AIF1 and neoplasm: We found that inhibition of macrophages with clodronate liposomes led to decreased TAM density (measured as IBA1+ area) from 8.9 ± 0.4 to 7.4 ± 0.3% (mean ± S.E.M., N = 6; Fig. 5f) and increased proliferation of tumour cells from 4.7 ± 0.3 to 7.4 ± 1% (Fig. 5g).