MAPT and tauopathy: On the other hand, P301S-Tau-Tg mice (tauopathy model) exhibited an age-dependent decline in CAPON protein (Fig. 2c), suggesting that severe pathology such as that associated with frontotemporal dementia with parkinsonism-17 (FTDP-17) mutant tau-induced cytotoxicity decreases the level of CAPON, presumably because the number of neuronal cells where CAPON is mainly expressed is reduced (Supplementary Fig. 6).