MYC and medulloblastoma: We observed similar synergy in two additional patient-derived MYC-driven intracranial medulloblastoma models: Med-114FH (Fig. 9b) and Med-411FH (Fig. 9c), which exhibited significantly prolonged survival when treated with both LEE011 and JQ1 compared to vehicle controls (p values 0.01 and 0.02) or treatment with JQ1 alone (p values 0.017 and 0.007).