GPC3, also known as DGSX, OCI-5, MXR7, GTR2-2, SDYS, SGB, SGBS1 and SGBS, belongs to the glypican-related integral membrane proteoglycan family (GPC1–GPC6) [8] and was recently identified to play a crucial role in the molecular mechanisms by which the malignant phenotype of HCC cells are modulated. This evidence concerns the gene GPC3 and hepatocellular carcinoma.