In addition, Aviel-Ronen et al. [12] explored the expression pattern of GPC3 in lung cancer for the first time and demonstrated that GPC3 was positively expressed in 55% of SCC versus 8% of adjacent cancer but negatively expressed in normal lung tissues, suggesting that the overexpression of GPC3 might play a role in the progression of lung SCC. Here, GPC3 is linked to lung carcinoma.