Treatment of breast cancer cells with SecinH3, a small molecule that could enhance Robo4 signaling by deactivating Arf6 activating proteins downstream of Robo4, significantly suppressed tumor growth, inhibited lung metastasis, reduced tumor aggressiveness and rescued the loss of the ZO-1 protein in ECs without inducing weight loss in mice [109]. This evidence concerns the gene ARF6 and neoplasm.