Wang et al. [30] discovered that Slit2/Robo1 signaling increased micro-vessel densities and the tumor volumes and masses in vivo, and Slit2-induced directional migration and tube formation of HUVECs were attenuated by phosphatidylinositol 3-kinase (PI-3K) inhibitors in vitro. The gene discussed is SLIT2; the disease is neoplasm.