The overall results suggested that STAT4 rs7574865 still correlated with CHB-related HCC (G vs. T: OR = 1.18, 95% CI: 1.07–1.31, PA=0.001; GG + GT vs. TT: OR = 1.26, 95% CI: 1.04–1.53, PA=0.02; GG vs. GT + TT: OR = 1.20, 95% CI: 1.06–1.37, PA=0.005). Here, STAT4 is linked to hepatocellular carcinoma.