An enrichment for malignancy terms was also noted (from the Molecular Signatures Database; first ranked term = Genes with promoters occupied by PML-RARA fusion protein in acute promyelocytic leukemia [APL] cells NB4 and two APL primary blasts, based on ChIP-seq data, fold enrichment = 3.14, binomial FDR Q-value = 6.18 × 10−7) (see Supplemental Data S2; Liberzon et al. 2011). The gene discussed is PML; the disease is acute promyelocytic leukemia.