Although the relevance of blood cells to understanding the etiology of TBRS is not yet known, we hypothesize that our findings will be generalizable across cell types given the ubiquitous developmental expression of DNMT3A and given that many age-associated DMPs are shared across different cell types (Zhu et al. 2018). This evidence concerns the gene DNMT3A and Tatton-Brown-Rahman overgrowth syndrome.