DNMT3A and Tatton-Brown-Rahman overgrowth syndrome: In the current study, we investigated the methylomic consequences of a DNMT3A pathogenic variant (NC_000002.12:g.25240312C > T; NM_022552.4:c.2312G > A; p.(Arg771Gln)) in a large Amish family comprising four individuals affected with TBRS arising as a result of a mosaic pathogenic DNMT3A variant in their father (Xin et al. 2017).