The average size of the LG in mxcmbn1/Y; Lsp2>Dl was 34% of that in mxcmbn1/Y; Lsp2>GFP (n>20) (Fig. 4B-D,H), indicating that ectopic activation of the Toll pathway by Dl overexpression in fat-body cells significantly suppressed the tumour overgrowth phenotype that appeared in mxcmbn1 larvae (P<0.0001, Welch's t-test) (Fig. 4C,D,H). This evidence concerns the gene TLR4 and neoplasm.