APOE and Anxiety: For reasons above, we aim to investigate the characteristics of the cortical surface area in individuals with SCD compared to controls, and whether APOE ε4 statue and neuropsychiatric symptoms (e.g., depressive and/or anxiety) influenced the cortical surface area, which may help improve the sensitivity of structural imaging studies to provide a separate morphologic index of SCD with genetic and neuropsychiatric risk factors.