Moreover, meta-analyses of clinical trials have illustrated an overall positive response to immunotherapy with PD-L1/PD-1 axis blockade in NSCLC patients and positive correlation between the PD-L1 tumor proportion score (TPS) (the percentage of PD-L1 expressing tumor cells determined by immunohistochemistry) and the response rate [25, 26]. Here, PDCD1 is linked to neoplasm.