We have investigated the presence of the OI type V c.-14C > T 5′UTR IFITM5 pathogenic variant in a cohort of OI patients negative for collagen I pathogenic variants with and without symptoms of OI type V. We have identified five individuals with OI type V from Ukrainian and Vietnamese origin with various phenotype severity. This evidence concerns the gene IFITM5 and osteogenesis imperfecta.