AKT1 and ovarian neoplasm: The previous data indicate two possible experimental hypotheses: first, the genes found in our screening may be altered in cultures that are enriched for CSCs and may therefore be markers of CSC enrichment in ovarian tumors; second, these “core” networks, the MAPK/AKT (involving C-KIT), NOTCH and DNA damage pathways, may be ideal therapeutic targets to recover platinum sensitivity.