Moreover, in models of apoptosis in human neuroblastoma cells and ischemia-reperfusion injury in retina, argon was proven to mediate neuroprotective effects via inhibiting the toll-like receptor (TLR)2/TLR4/signal transducer and activator of transcription (STAT)3/nuclear factor kappa B (NF-ҡB) pathway [25]. This evidence concerns the gene TLR2 and neuroblastoma.