PICALM and neuroblastoma: Despite these effects, PICALM generally does not appear to affect the general clathrin-mediated endocytosis uptake of cargo, but only that of specific proteins [75–77], such as vesicle-associated membrane proteins (VAMPs; i.e. VAMP-2, VAMP-3 and VAMP-8), as detected in HeLa and neuroblastoma cell lysates [75, 78].