In HeLa cells, PICALM co-localizes with ATG16L1 on autophagic precursors [45], whereas in frontal cortices of patients with different neurodegenerative diseases, including AD, PICALM levels inversely correlate with those of the autophagic markers LC3-II and Beclin-1 [44]. The gene discussed is PICALM; the disease is neurodegenerative disease.