Human induced pluripotent stem cell-derived monocytes and transdifferentiated microglia-like cells with lowered TREM2 expression or TREM2 loss-of-function show a similar impaired clearance of amyloid plaques in an ex vivo amyloid plaque clearance assay, comprising sections of mouse brains (6-month-old APP/PS1+/−) [149]. This evidence concerns the gene TREM2 and amyloidosis.