They found 1189 differentially methylated sites (false discovery rate < 0.05) and replicated Ventham’s previous findings at VMP1, SBNO2, RPS6KA2, ITGB2 and TXK. Of these, 194 showed genetic effects on the change in methylation, and using Mendelian randomisation approaches, they found evidence to suggest that three of these, two involving the gene GPR31 and one involving RNASET2, showed evidence of a causal relationship with Crohn’s disease, replicating a prior finding at RNASET2 [65]. Here, RNASET2 is linked to Crohn disease.