Focusing on the gene expression modulation associated to the cancer progression, we discovered many genes with a gradual increase of expression from S-NBE to S-EIF and to S-IBC, such as KIAA0368, KIAA1217, STAT2, TRAK1, DDX17, IGF2, HIPK3, AQP1, ACADVL, HSPG2, FLNA, NFE2L1, COL1A1, MXRA5, DYSF, SIN3B, JMJD1C and NOTCH2. The gene discussed is NOTCH2; the disease is cancer.