HMGCR and metabolic syndrome: Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase (HMGCR, EC 1.1.1.88), statins, are widely used in the primary and secondary prevention of cardiovascular diseases, efficiently lowering serum low density lipoprotein cholesterol (LDL-C) levels in patients with dyslipidemia [1].