Target genes for SREBP1 AND SREBP2 include key lipogenic genes such as acetyl-CoA carboxylase-alpha (ACACA), fatty acid synthase (FASN), fatty acid elongase-6 (ELOVL6) and stearoyl-CoA desaturase (SCD), involved in fatty acid (FA) biosynthesis from acetyl-coA, FA elongation and desaturation, all of them having been linked to the progression of insulin resistance and diabetes [30–33]. The gene discussed is ACACA; the disease is diabetes mellitus.