Many NP drug delivery systems are being developed, such as Au-NP conjugated to siRNA against NADPH Oxidase 4, Au-NP carrying plasmid DNA encoding for murine IL-2, PLA-NP carrying Gag p24 HIV-1 antigen, B6 peptide conjugated to PEG-PLA-NP encapsulating the neuroprotective peptide NAPVSIPQ to Alzheimer’s disease mice model, and others [51, 69–71]. This evidence concerns the gene NOX4 and Alzheimer disease.