In contrast, in asthmatic children treated with low dose prednisolone (5 mg daily) for 1 week, IGF bioactivity was diminished despite unaltered total and free IGF-I [12], and IBD patients on 8–12 weeks prednisolone demonstrated increased total IGF-I, whereas free IGF-I was unchanged in patients with Crohn’s disease and increased in ulcerative colitis [41]. The gene discussed is IGF1; the disease is ulcerative colitis.