TP53 and cancer: Furthermore, FBXO11 also acts as a nedd8 ligase for the tumour suppressor gene TP53 by mediating the NEDDylation of p53 protein [13, 14], and transcriptionally inactivating TP53. FBXO11 also promotes the ubiquitin-driven degradation of Snail, a transcription factor mediating the epithelial-mesenchymal transition (EMT) during cancer progression and metastasis [15].