VHL and nonpapillary renal cell carcinoma: The Beroukhim Renal microarray datasets [18] showed that FBXO11 expression in normal tissue was notably lower than that in both non-hereditary and hereditary ccRCC (P < 0.001, F = 13.61, Fig. 1c), as well as than that in VHL mutant and wild-type ccRCC (P < 0.001, F = 13.30, Fig. 1d).