Another study by Zhang D et al. [18] including 1339 patients in the general intensive care units demonstrated that when Cystatin C (Cys C) was used for detecting early AKI, FT3 was found to be independently associated with Cys C. Furthermore, FT3 had no significant impact on the diagnostic and predictive accuracy of Cys C in detecting AKI in ICU patients. The gene discussed is CST3; the disease is acute kidney injury.