In the group of individuals with a personal history of breast cancer, 34.9% (268/768) received at least one VUS in their report with 2.6% (20/768) having a VUS in the BRCA1/2 genes, 15.2% (117/768) in other high-risk genes for breast cancer (CDH1, PTEN, STK11, TP53, and PALB2), 10.7% (82/768) in moderate-risk genes for breast cancer (ATM, CHEK2 and NBN) and 6.4% (49/768) in low-risk genes or with limited information. The gene discussed is PALB2; the disease is breast cancer.