Additionally,24 the heterozygous loss of PHLPP2 has been reported to be associated with reversing the development of breast cancer, liver cancer, and ovarian cancer.25,26 TPM2, one of the tropomyosin proteins, participates in the regulation of muscle contraction by forming complexes with actin and troponin, and is involved in cellular biological activities (cell invasion, etc).27 In addition, more than 40 subtypes of this type of tropomyosin are derived from the 4 categories (TPM1-4). This evidence concerns the gene TPM2 and breast cancer.