PTEN and neoplasm: For the induction of senescence in tumor cells by genotoxic stress or the reactivation of growth-suppressive pathways, the reactivation or re-expression of p53, the inactivation of Myc or Bcr-Abl, and the inhibition of Pten are attractive therapeutic approaches and have been shown to potentiate growth inhibition or tumor regression [59,60,61].