A conditional marketing authorization was granted by the EMA in 2012 for the restricted treatment of adult patients with relapsed or refractory CD30+ Hodgkin lymphoma after ASCT or after at least two previous therapies when ASCT or multiagent therapy is not a treatment option and for the treatment of adult patients with relapsed or refractory sALCL [44]. This evidence concerns the gene TNFRSF8 and Hodgkins lymphoma.