Interestingly, we found here that CAFs expressing integrin α11 do not systematically co-express αSMA, since we noted a strong co-expression of integrin α11 and αSMA in CAFS around the tumor cells of the PDAC and HNSCC sections, which suggested that these α11+-CAFs could have a role in collagen remodeling at the border of the tumor in order to facilitate tumor cell invasion. This evidence concerns the gene ACTA1 and head and neck squamous cell carcinoma.