Allergy immunotherapy is a type of treatment targeting the basic immunological molecules and immunological pathways involved in allergic reaction and resulting in the activation of immunological tolerance by reducing IgE molecule reactivity and retaining T cell molecule reactivity [24].A vast array of structurally altered allergens has been created, including allergenic oligopeptides, chemically modified allergoids, adjuvant-bound allergens, and nanoparticle-based allergy vaccines. The gene discussed is IGHE; the disease is allergic disease.