For example, miR-186a, a hypoxia-responsive microRNA that is an inhibitor of HIF1A-induced tumor proliferation in gastric cancer [76], has also been shown to be downregulated during fibroblast transformation, leading to an increased expression of GLUT1 and a glycolytic phenotype in cancer-associated fibroblasts (CAFs) [77]. Here, HIF1A is linked to cancer.