Furthermore, newly developed CAR T cells such as tandem CAR T cell (which harbor two ligand-binding domains), multi-CAR T cells (which harbor different chimeric antigen receptors), built-in-CAR T cells (which are modified to release anti-PD-L1 antibodies within the tumor), and many others have already been generated, mainly with the aim to potentiate the efficacy or reduce the toxicities [66,67,68]. The gene discussed is CD274; the disease is neoplasm.