BAX and cancer: The situation is different in the case of mtKv1.3: block of depolarizing K+ influx via mtKv1.3 by BAX [35,160] or specific membrane-permeant inhibitors [156,160] was shown to cause IMM hyperpolarization, increase of ROS release, PTP activation, swelling, loss of mitochondrial membrane potential (Δψm), loss of cytochrome c and further ROS release (Figure 6), allowing the cancer cells to reach a critical threshold of oxidative stress, as they are characterized by a higher basal ROS level with respect to healthy cells [161].