MCU and colorectal cancer: More recent work highlights that the receptor-interacting protein kinase 1 (RIPK1) that is upregulated in human colorectal cancer interacts with mitochondrial Ca2+ uniporter (MCU) to promote proliferation by increasing mitochondrial Ca2+ uptake and energy metabolism [136], suggesting that the RIPK1-MCU pathway is a promising target to treat colorectal cancer.