Despite the link between oxidative stress and KEAP1 has been widely clarified in NSCLC and KEAP1 mutations, representing one of the main features of these histologies [11,34], a clear association between epigenetic KEAP1 promoter hypermethylation has not yet been found in NSCLC, and molecular data regarding this deregulation mechanism in lung neuroendocrine tumors are limited [35]. The gene discussed is KEAP1; the disease is lung neuroendocrine neoplasm.