Luminal and basal subtypes of both primary and relapsed NMIBC contained sufficient CD8+ T cell populations varied from 22.5% up to 33.4% of the tumor nodes stromal compartments; whereas the presence of T-suppressors in primary and relapsed p53 mutant subtypes of NMIBC was no more than 5.4% in the case of primary tumor. This evidence concerns the gene TP53 and neoplasm.