EGFR and neoplasm: In addition, as shown in Table 3, EGFR CNA’s (polysomy or amplification) were associated with young age (chi-square trend test, p = 0.04), advanced tumor stage (p = 0.01), a higher grade of tumor differentiation (p = 0.03), and LNM (p < 0.01), but not with tumor site, AQ chewing, cigarette smoking, or alcohol drinking.