NFKB1 and hypertensive disorder: Concerning anthocyanins, the only subclass of flavonoids that was significantly associated with decreased risk of hypertension in the present study, their effects involve targeting the NF-κB signaling pathway, activator protein 1(AP-1), the Phase II enzyme activation and Nrf2, and the mitogen-activated protein kinase (MAPK) signaling pathway [80].