AKT1 and neoplasm: In contrast, the levels of PTEN, a well-known tumor suppressor that deactivates the phosphatidylinositol 3-kinase (PI3k)-Akt pathway, did not change significantly after miR-150 mimic transfection (0.68-fold decrease, p = 0.180, 54 kDa) (Figure 6A,B).