Second, although there are previous reports that p27Kip1 is decreased in leiomyoma compared to matched myometrium [50,51], in order to draw a precise conclusion, reconfirming the baseline expression level of p27Kip1 in leiomyoma using same samples which were used assessing changes of Akt and p27Kip1 after miR-150 transfection is necessary. The gene discussed is AKT1; the disease is leiomyoma.