TP53 and breast carcinoma: In contrast to these evidence, Vasilaki and colleagues reported that in p53 mutant breast cancer activation of Ras or TFGβ signaling induces the degradation of mutant p53, releasing ΔNp63 transcriptional activity towards two target genes, dual specificity phosphatase 6 and 7 (DUSP6 and DUSP7) [81].