TP63 and neoplasm: Although these studies unveil a potential functional link between the TAp63 tumor suppressor activity and stem cells homeostasis in breast tumors, they hardly align with previous studies showing that ΔNp63 is the only p63 isoform expressed in mammary stem cells, capable of regulating mammary stem cells activity and promoting breast cancer initiation in basal-like or luminal-like breast cancers.