Similarly, the genomic promoter-capture Hi-C analysis (see Fig E1) provides more support for a possible promoter-promoter interaction between the GWAS locus and LRRC32 than EMSY, suggesting that an effect through LRRC32 expression in keratinocytes or T cells might also play a role in the pathogenesis of AD. The gene discussed is LRRC32; the disease is Alzheimer disease.