PTPA and cancer: Apolipoprotein E-derived peptides such as COG1410 also bound to SET, activated PP2A (Christensen et al., 2011) and exerted anti-tumor effects in several experimental models of cancer (Agarwal et al., 2014; Christensen et al., 2011; Fujiwara et al., 2013; Hu et al., 2015; Richard et al., 2016; Shlomai et al., 2017; Switzer et al., 2011).