These molecules cannot be phosphorylated or bind to S1PRs, but retain the SET-binding, PP2A-activating and anti-tumor properties of their parent (Mani et al., 2015; Mani et al., 2017; Omar et al., 2011; Omar, Tolba, Hung, & Al-Tel, 2016; Roberts et al., 2010; Smith et al., 2016). This evidence concerns the gene PTPA and neoplasm.