MAPT and Alzheimer disease: According to the tau hypothesis, the formation of NFTs is the key pathogenic process driving neuronal dysfunction and death, not only in AD but also in other neurodegenerative conditions collectively known as tauopathies (Iqbal et al., 2010; Sabbagh & Dickey, 2016; Sontag & Sontag, 2014; Voronkov, Braithwaite, & Stock, 2011; Ward, Himmelstein, Lancia, & Binder, 2012).