G6PC3 and hyperinsulinemic hypoglycemia, familial, 4: IBD-like colitis has been described in at least 8% of patients with G6PC3 deficiency.14,24 Patients present with Crohn’s-like inflammation, frequent stricture formation and severe oral aphthous ulceration.12–14,24 Myeloid cells are particularly dependent on G6PC3, lacking compensatory alternative phosphatases [Supplementary Figures 1–3].