Both PET and cerebrospinal fluid data indicate that synergy between Aβ and tau is associated with brain dysfunction,16,30 atrophy,14,31,32 and cognitive decline.33,34 We observed that Aβ and tau in inferior temporal neocortex interacted and potentiated tauopathy (model 5) and cognitive decline (model 8). This evidence concerns the gene MAPT and Atrophy.