SOD1 and amyotrophic lateral sclerosis: ALS mutations in SOD1, TARDBP (TAR DNA-binding protein 43 kDa), FUS (Fused in Sarcoma) and C9ORF72 generate proteins with a propensity to misfold and aggregate (Bruijn et al., 1998; Neumann et al., 2006; Deng et al., 2010; Zu et al., 2013).