p62 is a ubiquitin-binding protein and a common component of ubiquitinated inclusions in degenerating SpMNs of ALS patients and mouse models (Seibenhener et al., 2004; Liu et al., 2016; Mizuno et al., 2006; Gal et al., 2007). This evidence concerns the gene SQSTM1 and amyotrophic lateral sclerosis.