To define the role of METex14 in mediating resistance to EGFR TKIs, we generated two isogenic EGFR-mutant non–small-cell lung cancer (NSCLC) cell models using PC9 (exon 19 deletion) and H1975 cells (L858R and T790M) by transduction with lentiviral vectors driving expression of METex14 (Fig 2A). Here, EGFR is linked to lung cancer.