Contrastingly, overexpression of β1,4-N-acetylglucosaminyltransferase III (MGAT3), which adds β1,4 bisecting branches to N-glycans, appears to inhibit EGFR sensitivity to EGF in glioma cells (58), thereby reducing cellular response to the proliferative effects of EGF. The gene discussed is EGF; the disease is central nervous system cancer.