Moreover, numerous cell-surface tyrosine kinase receptors (RTK), including EGFR, FGFR, PDGF, c-MET, ERBB2/HER2, and IGFR are known to be regulated by cancer-associated glycans (58–60), glycosyltransferases (61), and proteoglycans (62–65). This evidence concerns the gene ERBB2 and cancer.