CAF-derived proteoglycans, as decorin, further suppress immunomodulatory genes in triple-negative orthotopic breast carcinoma xenografts, including Siglec (Sialic acid binding Ig-like lectin), Lipg (IFNγ inducible GTPase), and Il1b (Interleukin 1β) (213). Here, DCN is linked to breast carcinoma.