In this context, tumor-infiltrating immune cells frequently develop immunosuppressive activities, differentiating into regulatory T cells (Tregs), immature monocytes, and alternatively activated macrophages, mast cells, neutrophils, dendritic cells (DC), and T helper 2 (TH2)-CD4+ T cells, all of which producing a multitude of factors aiding tumor growth and survival (264). The gene discussed is CD4; the disease is neoplasm.