HGF and hepatocellular carcinoma: Moreover, core 1 β1,3-galactosyltransferase (C1GALT1, responsible for Tn antigen biosynthesis) overexpression in hepatocellular carcinoma activates hepatocyte growth factor (HGF) signaling via modulation of MET kinase O-glycosylation and dimerization, thereby enhancing cell proliferation in vivo and in vitro (61).