Furthermore, the extracellular matrix proteoglycan versican has been shown to promote bladder cancer-derived lung metastasis through enhanced tumor cell migration and creation of an inflammatory environment involving macrophages and pro-tumor CCL2/CCR2 signaling axis (262, 263), providing another the involvement of glycoconjugates in macrophage-mediated inflammation. The gene discussed is CCL2; the disease is neoplasm.