CD4 and neoplasm: It possesses a variety of immunomodulatory functions, synergism and reduced toxicity, including inhibiting growth and migration of CD4+CD25+Treg cells (44), enhancing the cellular activity of macrophages (45), increasing the sensitivity of cervical cancer HeLa cells and ovarian cancer SKOV3 cells to cisplatin (46, 47), etc. Recent research has focused on its anti-tumor activity for effective interventions in gastric cancer and liver cancer (48, 49).