NOP10 as an H/ACA RNP contributes to telomerase enzyme assembly and stabilization, post-transcriptional processing of nascent ribosomal RNA and pre-mRNA splicing. Therefore, it is essential for ribosome biogenesis, pre-mRNA splicing, and telomere maintenance (105, 106) NOP10 mRNA level was reported to be decreased in patients with chronic lymphocytic leukemia (CLL) relative to controls (105). This evidence concerns the gene NOP10 and B-cell chronic lymphocytic leukemia.