TERT and neoplasm: These proteins are involved in regulating multiple cellular functions via their interaction with phosphorylated partners. An elevated level of 14-3-3 proteins facilitates tumor progression in a variety of malignancies. The observations of Seimiya et al. identified the 14-3-3 signaling proteins as human TERT (hTERT)-binding partners and suggested that 14-3-3 improves nuclear localization of TERT. A dominant-negative 14-3-3 redistributed hTERT into the cytoplasm, which was normally localized in the nucleus (77)