TCAB1 is a subunit of active telomerase and is essential for the telomerase holoenzyme to be accumulated in Cajal bodies and to elongate telomeres (111), so it is involved in Cajal body maintenance, telomere maintenance and ribonucleoprotein biogenesis. Overexpression of TCAB1 seen in head and neck carcinoma clinical specimens as well as in carcinoma cell lines while depletion of TCAB1 decreased cellular proliferation and invasion potential both in vitro and in vivo (112). This evidence concerns the gene WRAP53 and head and neck carcinoma.