TEP1 is overexpressed in tumor cells compared to normal cells and it contributes to carcinogenesis and progression of renal cell carcinoma, bladder and prostate cancer (109). Additionally, Findings of Kohno study suggest TEP1 plays a role as a tumor suppressor gene in the genesis and progression of human lung cancer (110). This evidence concerns the gene TEP1 and hereditary clear cell renal cell carcinoma.