DKC1 and B-cell chronic lymphocytic leukemia: GAR1 is one of the four H/ACA RNPs. It also involved in telomerase assembly and stabilization, post-transcriptional processing of nascent ribosomal RNA and pre-mRNA splicing. All these RNPs are concentrated in nucleoli and Cajal bodies of mammalian cells, reflecting the location of H/ACA RNPs. GAR1 binds only to Dyskerin and it is crucial for the nucleolar localization and function of the RNP complex. In CLL patients, a significant decrease of GAR1 mRNA level in patients with CLL compared to controls (105)