MYD88 and thromboangiitis obliterans: Aplin et al. (83) observed that in a mouse model of the aortic vascular injury accompanied with angiogenesis, the overexpression of TLRs, the stimulation of TLR signaling pathways, and the promotion of downstream gene sequences occurred, while differently in the MyD88 knockout mouse cell culture, the induction of angiogenesis was inhibited following aortic injury, which is indicative of the implication of MyD88 in the TAO pathogenesis.