CFH and C3 glomerulonephritis: Consequently, the majority of pathogenic variants within the CFH gene lead to phenotypes related to disturbed immune processes including aHUS/TMA, C3-glomerulopathy (including dense deposit disease and C3 glomerulonephritis) or age-related macular degeneration (AMD) (Boon et al., 2008; de Córdoba and de Jorge, 2008; Morgan et al., 2012).