The data obtained showed that the natural aging and the premature aging in HGPS are mediated by similar signaling pathways, such as downregulated DNA repair, chromatin organization, caspase, and EGFR pathways, and upregulated ERK, mTOR, GH-IGF1, MAPK, TGFβ, mitochondrial dysfunction, and some other pathways. Here, MTOR is linked to Hutchinson-Gilford progeria syndrome.